刘定斌,博士,教授,分析科学研究中心,中心副主任,毕业于中国科学院,贵州修文人。
工作内容:教学科研
人才称号:国家“四青”人才、天津市级青年学术带头人
通讯地址:学院中心实验室B313
电 话:022-23497707
电子邮件:liudb@nankai.edu.cn
课题组网站:http://liulab.sklmcb.nankai.edu.cn/
研究领域:
1. 利用先进的分离富集技术助力肿瘤标志物筛选
2. 发展高灵敏、高特异性的肿瘤检测探针
3. 建立面向临床转化的体外诊断新方法
招生学科:分析化学
教育及科研经历:
2002-2006 兰州大学 学士
2006-2009 中科院成都生物所 硕士
2009-2012 国家纳米科学中心 博士
2012-2014 美国国立卫生研究院 博士后
2014 至今 新葡的京集团3512vip 研究员、教授/博导
学术任职
2017-至今 《Nanotheranostics》副主编/编委
2018-至今 中国生物医学工程协会青年委员
2018-至今 中国抗癌协会青年委员
2019-至今 《高等学校化学学报》青年编委
2022-至今 中国研究型医院学会细胞外囊泡研究与应用专业委员会委员
2023-至今 中国生物材料学会体外诊断分会委员
科研成果与代表作
近年来,已在生物医学检测和临床诊断领域发表论文90余篇,他引5500余次。近五年作为通讯作者在Proc. Natl. Acad. Sci. U.S.A.、Sci. Adv.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nano Lett.、ACS Nano、JACS Au、J. Extracell. Vesicles、Anal. Chem.等国际知名刊物上发表论文38篇,多篇论文被选为期刊封面、Hot Paper及 ESI 高被引论文;申请中国专利10项,已授权5项;荣获2019年中华医学会青年科技奖、第二届 “天津青年创新能手”称号等荣誉;获得国家重点研发计划和国家自然科学基金委的持续资助,主持项目的经费总额逾千万元。
近期发表的代表性论文如下:
(1) Qiang Li, Zhaowei Zhang, Fengchao Wang, Xiang Wang, Saisong Zhan, Xiaoqing Yang, Chen Xu, Dingbin Liu*, Reversible zwitterionic coordination enables rapid, high-yield, and high-purity isolation of extracellular vesicles from biofluids. Science Advances, 2023, DOI: 10.1126/sciadv.adf4568.
(2) Zhiyou Zong, Xinzhuo Liu, Zhuo Ye, and Dingbin Liu*, A Double-switch pHLIP system enables Selective Enrichment of Circulating Tumor Microenvironment-derived Extracellular Vesicles. Proceedings of National Academy of Sciences of the United States of America, 2023, 120(2): e2214912120.
(3) Zhaowei Zhang, Xuehui Liu, Xiaoqing Yang, Ying Jiang, Ang Li, Jiying Cong, Yuwei Li, Qinjian Xie, Chen Xu*, and Dingbin Liu*, Identification of Faecal Extracellular Vesicles as Novel Biomarkers for Non-invasive Diagnosis and Prognosis of Colorectal Cancer. Journal of Extracellular Vesicles, 2023, 12(1): 12300.
(4) Wenshuai Li, Jingjing Wang, Chen Li, Zhiyou Zong, Jinzhong Zhao, Hongmei Gao, and Dingbin Liu*, Achieving Ultrasensitive Chromogenic Probes for Rapid, Direct Detection of Carbapenemase-Producing Bacteria in Sputum. JACS Au, 2023, 3(1): 227-238.
(5) Fengchao Wang, Ning Sun, Qiang Li, Jie Yang, Xiaoqing Yang, and Dingbin Liu*, Self-Referenced Synthetic Urinary Biomarker for Quantitative Monitoring of Cancer Development. Journal of the American Chemical Society, 2023, 145(2): 919-928.
(6) Zhuo Ye, Moxuan Ji, Kefeng Wu, Jie Yang, An-an Liu, Wei Sun, Dan Ding, and Dingbin Liu*, In-Sequence High-Specificity Dual-reporter Unlocking of Fluorescent Probe enables the Precise Identification of Atherosclerotic Plaques. Angewandte Chemie International Edition, 2022, 61(29); e202204518.
(7) Xuehui Liu, Zhiyou Zong, Xinzhuo Liu, Qiang Li, Ang Li, Chen Xu*, and Dingbin Liu*, Stimuli-mediated Specific Isolation of Exosomes from Blood Plasma for High-throughput Profiling of Cancer Biomarkers. Small Methods, 2022, 6(2): 2101234.
(8) Xinzhuo Liu, Zhiyou Zong, Mindan Xing, Xuehui Liu, Jia Li, and Dingbin Liu*, pH-Mediated Clustering of Exosomes: Breaking Through the Size Limit of Exosome Analysis in Conventional Flow Cytometry. Nano Letters, 2021, 21(20): 8817-8823.
(9) Cai Zhang, Xinzhuo Liu, Zhiwen Xu, and Dingbin Liu*, Multichannel Stimulus-Responsive Nanoprobes for H2O2 Sensing in Diverse Biological Milieus. Analytical Chemistry, 2020, 92(18): 12639-12646.
(10) Yingna Bi, Huixia Di, Erzao Zeng, Qiang Li, Wenshuai Li, Jie Yang, and Dingbin Liu*, Reliable Quantification of pH Variation in Live Cells Using Prussian Blue-Caged Surface-Enhanced Raman Scattering Probes.' Analytical Chemistry, 2020, 92(14): 9574-9582.
人才培养
已培养博士后5名,博士生10名,硕士生15名。
本课题组每年拟招收1-2名博士生,1-2名硕士生。